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J Hazard Mater 164(23):13041309

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Mitochondria morphological changes are associated with dysfunction and altered energy metabolism, whereby adenosine triphosphate (ATP) production is insufficient to maintain the Na+/K+-ATPase neuronal activity, which leads to massive calcium (Ca +2 ) influx followed by glutamate toxicity [24]

For instance, oridonin has been found to enhance the mRNA expression of various CYP enzyme families (1a, 2a, 2d, 2e, 2c, and 3a) and induce CYP enzyme activity

41 Data from renal cancer patients suggest that, depending on the secondary site, metastases manifest clinically at different timepoints, with a median of 15 years for pancreatic metastases but only 3 years for all other sites when compared with initial diagnosis