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Oxidation of cysteine S-conjugates by rabbit liver microsomes and cDNA-expressed flavin-containing mono-oxygenases: studies with S-(1,2-dichlorovinyl)-L-cysteine, S-(1,2,2-trichlorovinyl)-L-cysteine, S-allyl-L-cysteine, and S-benzyl-L-cysteine

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After endocytotic uptake and retrograde transport through the Golgi and ER to the cytosol, the K28 -subunit is ubiquitinated and proteasomally degraded, and the -subunit exerts its lethal effect in the nucleus, blocking DNA synthesis, causing cell-cycle arrest in early S phase

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