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The loss of GSH through the membrane may in turn depend on membrane oxidative stress, because oxidative stress causes lipid peroxidation of cell membrane, leading to altered membrane permeability and transport functions and consequently increased GSH efflux [36]

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While forming the dimeric structure, domain I of one subunit and domain II of the second interact with each other by the lock-and-key principle

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In this review we will analyze the role of GSH in the intestine, the molecular mechanisms by which GSH depleting drugs inhibit the intestinal Ca 2+ absorption and the prevention or restoration of these effects by drugs that act through normalization of intestinal GSH content