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Structure-based optimization yields superior degrader ZZ2 A preliminary structureactivity relationship study of ZZ1 indicated that the ortho -chloro substituent is essential for potency, while substitution with other functional groups failed to yield more effective YPEL5-dependent BRD4 degraders (Supplementary Table 4)

doi: 10.1038/s41551-020-0549-2 73 IshiharaJIshiharaASasakiKLeeSSYWillifordJMYasuiMet al

23., ozone is dosed via titanium microporous aerator from the bottom column of contact reaction to realize the contact of gas and water in a reversal way

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Plants are consistently encountered by various biotic and abiotic stresses (Zhao et al., 2021)

doi: 10.1016/j.clnu.2011.02.009 65