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The absence of a boxed warning on cagrilintide reflects the absence of an approved label not a demonstration that it is safer

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These design features yield a pharmacokinetic profile suitable for once-weekly administration, with a reported elimination half life of 78 days (DAscanio et al

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A long-acting amylin analog being evaluated in research environments

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Monotherapy-versus-combination asymmetry

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Both support once-weekly dosing, and a longer half-life says nothing about efficacy or safety on its own

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PMID 34170647

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