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Cancer Research UK

A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines

Affected individuals have thiamine deficiency that does not respond to ordinary thiamine and are usually misdiagnosed

Christie B

A first step in overcoming these problems would be an assessment of anti-angiogenic drugs in clinical trials where patients are selected according to predictive biomarkers (e.g., the vascular pattern)

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