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First, glutamine helps in offsetting sugar cravings by communicating with the brain via glutamine-sensing neurons in the mucosal lining of the gut

Amyloid-beta directly interacts with mitochondrial membranes, impairing ETC function, increasing ROS production, and blocking communication between lysosomes and mitochondria in vivo

doi:10.1021/acs.molpharmaceut.5b00501 39

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Furthermore, based on mechanistic insights, the review explores targeted gut microbiota interventions, systematically evaluating clinical evidence for dietary modifications, probiotic/prebiotic supplementation and fecal microbiota transplantation