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10.1146/annurev-immunol-031210-101322 Annu

It also regulates pineal gland function, supporting circadian rhythms and hormonal health

CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis

Paget observed that primary tumor cells of a given type of cancer preferentially metastasized to one or more particular distant organ sites, detectable metastases only developed at those sites (soils) where the tumor cells (seeds) were adapted for survival and proliferation [21]