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A double-blind randomized placebo-controlled study pointed out the efficacy of smoking a marijuana cigarette, containing 1.54% A9-tetrahydrocannabinol, in improvement of spasticity, neuropathic pain, urinary complications, and sleep disorders (Greenberg et al., 1994

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M.SwerdlowP.SaunthararajahY.CastroO.et al (2008)

Country API FDF Both CMO Total India 214 135 21 26 396 US 83 143 13 89 328 China 128 45 12 12 197 Italy 59 3 2 19 83 Germany 25 4 1 15 45 Spain 30 9 1 4 44 Canada 7 17 13 37 Taiwan 9 6 5 4 24 Switzerland 15 4 4 23 France 16 6 22 Japan 18 1 19 United Kingdom 12 1 2 15 Mexico 9 1 1 11 Ireland 5 5 1 11 Generic Drug Facilities Registered with the US FDA for FY2025 (Free Excel Available) GDUFA III user fee rates increase across categories for FY25The GDUFA, which was reauthorized on September 30, 2022 (as GDUFA III), continues with provisions that will last until September 30, 2027

3.13 Other pharmacological effects In addition to the previously discussed bioactivities, catalpol has been reported to treat a wide range of conditions, including hemorrhage, vitiligo, Sjogrens syndrome, Guillain-Barr syndrome, chronic inflammatory pain, bone marrow suppression, thyroid dysfunction, aging, depression, pancreatitis, demyelination, burns, polycystic ovary syndrome (PCOS), Duchenne muscular dystrophy (DMD), allergic asthma, blood deficiency syndrome, and other diseases

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