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NCT04449029) 1485-C RECOMBINANT MOSAIC HBV CAPSID PARTICLES FOSTER ADAPTIVE IMMUNITY AGAINST THE MOST PREVALENT HBV GENOTYPES BY THERAPEUTIC VACCINATION Shubhankar Ambike 1 , Julia Sacherl 1 , Alexander Seidler 1 , Arie Geerlof 2 , Anna Kosinska 1,3 , Sophia Schreiber 1 , Frank Thiele 1 , Tanja Bauer 1,3 , Michael Nassal 4 , Anne Schtz 5 and Ulrike Protzer 3 , (1)Institute of Virology, School of Medicine, Technical University of Munich and Helmholtz Munich, Germany, (2)Institute of Structural Biolology, Helmholtz Munich and Technical University of Munich, Germany, (3)German Center for Infection Research, Munich Partner Site, Germany, (4)University Hospital Freiburg, Internal Medicine 2/Molecular Biology, University of Freiburg, Germany, (5)Faculty of Chemistry and Pharmacy, Ludwig Maximilian University of Munich, Germany Background: Hepatitis B virus (HBV)-specific B- and T-cell responses are key to cure HBV

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However, using recognizable spectrophotometric features that are indicative of the catalytic sequence, most particularly three charge transfer absorption transitions, permits assignment of the order of specific common catalytic events that in turn has indicated function for four of the five variants studied

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