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Leaky gut syndrome has been implicated as a factor in many medical conditions, including celiac disease, Crohns disease, Irritable Bowel Syndrome (IBS), and some autoimmune diseases, though whether it is a cause or consequence of those diseases remains unclear

Running distance, food intake and body weight were measured daily before dosing of experimental compounds

Transcriptomic analysis revealed significant differences between expression signatures of Nrf2 WT and KO cells, showing 1,566 up-regulated and 5,272 down-regulated genes in the Nrf2 KO condition compared with the WT (Fig 6A)

doi: 10.1038/s41413-021-00168-8 115 QuS.HuT.QiuO.SuY.GuJ.XiaZ

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Your doctor will assess you after 6 months to see if you have lost at least 5% of your starting body weight