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Activation of G protein-coupled receptors (GPRs) on immune cell membranes by butyric acid leads to an increase in cytoplasmic calcium levels, and an increase in calcium concentration leads to the activation of NLRP3 inflammatory vesicles and subsequent activation of caspase - 1

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doi: 10.1155/2013/965212 214 ParkHTChoGJAhnKHShinJHHongSCKimTet al

The Lancet 330:12191220

Tyrosinemia: the Quebec experience