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in severe cases, it can progress to sepsis and induce MODS or even death of heatstroke patients and mouse models [19]

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The HPG axis is responsible for the production of testosterone, the main sex hormone in males, other sex steroid hormones (dehydroepiandrosteroneDHEA, androstenedione, dihydrotestosterone, estrogen, and progesterone), peptide hormones (activin, inhibin, and follistatin, which are included in feedback mechanisms and spermatogenesis), production of spermatozoa (sperm cells), and sexual arousal (11, 15)

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