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All analyses were performed using JMP Pro 16 software (SAS Institute, Cary, NC, USA)

Anandhan A, Lei S, Levytskyy R, Pappa A, Panayiotidis MI, Cerny RL, et al

The preoperative loading dose ranged from 36 IU/kg to 99 IU/kg (median: 60 IU/kg) and the total post-operative dose ranged from 23 IU/kg to 769 IU/kg (median: 183 IU/kg)

Veenemans, J

Clinically, DEX reduces opioid requirements and facilitates ventilator weaning, although postoperative outcomes remain inconsistent (238242)

SS disulphide linking group a candidate can be evaluated by incubation with dithiothreitol (DTT), or other reducing agent using reagents know in the art, which mimic the rate of cleavage which would be observed in a cell, e.g., a target cell