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Murdaca G, Negrini S, Greco M, Schiavi C, Giusti F, Borro M, Puppo F

Gene replacement for lung cancer

Silico docking (Schrodinger Inc., Small-Molecule Drug Discovery Suite, 2016-1) revealed that benserazide binds to the active site of CBS (PDB ID: 1JBQ) and reacts with the PLP cofactor to form a reversible but kinetically stable Schiff base, and its trihydroxybenzyl ring can form hydrogen bonds with polar residues located in the peripheral cavity (such as His203, Tyr223, and Tyr308), resulting in strong inhibition

By facilitating Phase 2 liver detoxification, neutralizing the ROS that trigger mast cell degranulation, and protecting the autonomic nervous system from neuroinflammation, glutathione addresses the root metabolic dysfunctions driving these interconnected conditions

In a double-blind, placebo-controlled study in which blood GSH was measured in healthy subjects at several stages, 500 mg of vitamin C taken daily for 2 weeks significantly raised erythrocyte (red blood cell) glutathione levels