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Mechanistically, the authors reported that the uremic toxin, indoxyl sulfate, activates the aryl hydrocarbon receptor (AhR), and experiments using AhR knockout mice confirmed that AhR activation is a key driver of BBB damage (Bobot et al., 2020)

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Why it matters: Short telomeres are associated with cellular senescence (aging) and disease

The protein samples were digested by adding Trypsin (Thermo Scientific) at a 1:20 ratio (w/w) and incubated at 37C overnight