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While these medications have a relatively low intrinsic risk of causing dangerously low blood sugar when used alone, the risk increases significantly when combined with insulin or sulfonylureas

Shankar M, Wood S, Sharifi M, Costa D, Canavan M, McNamara M, Camenga D

Findings from rodent studies show that diet-induced obesity leads to increased microsomal ethanol oxidation (115), and clinical research suggests that obesity is associated with a higher alcohol elimination rate (116) and increased CYP2E1-mediated clearance of acetaminophen (117)

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The wording relating to echocardiogram assessment and REMs has not changed