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This suggests that the proper functioning of ERK2 is necessary before the antidepressant effects of testosterone can occur

D., Bukowski, R

Received October 25, 2025

On the other hand, TMAO decreases expression of two key enzymes, CYP7A1 and CYP27A1, essential for bile acid biosynthesis and multiple bile acid transporters (OATP1, OATP4, MRP2 and NTCP) in the liver, which decreases bile acid pool, resulting in decreased reverse cholesterol efflux (Koeth et al., 2013)