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K m values for both homocysteine and cysteine were essentially identical for the four constructs at ~0.3 and ~20 mM, respectively

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[DOI] [PubMed] [Google Scholar] 233.Wani TU, Khan RS, Rather AH, Beigh MA, Sheikh FA

As a result, they fail to provide efficient perfusion, leading to heterogeneous oxygen distribution within the tumor mass (170)