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Leslie SW, Brown LM, Trent RD, Lee Y, Morris JL, et al

The BK channel opener BMS-191011 was shown to suppress behavioral evidence of salicylate-induced tinnitus in mice, with local application in the inferior colliculus reversing salicylate-suppressed spontaneous activity, particularly in the frequency region corresponding to the tinnitus percept, highlighting a key site of action see in Figure 2 - (Scott et al., 2022)

Plant Cell Environ 39:951964 Foyer CH, Souriau N, Perret S, Lelandais M, Kunert KJ, Pruvost C, Jouanin L (1995) Overexpression of glutathione-reductase but not glutathione synthetase leads to increases in antioxidant capacity and resistance to photoinhibition in poplar trees

A larger group is on the FDA review track but cannot be dispensed until the process completes

For example, studies have shown that several signaling pathways implicated in depressionsuch as the PI3K-Akt and MAPK pathwaysoccupy central positions within depression-related proteinprotein interaction networks

There is no published phase 2 dose finding study in humans for any indication