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However, despite these limitations, the results collectively emphasize the crucial role of Nrf2-mediated oxidative stress in regulating the pathogenesis of RA, providing new insights for the clinical treatment of this condition (Fig

Amraei, R

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Beyond the extensively studied NRF2 pathway, which has been developed as a therapeutic target [502, 503], the PI3K/AKT/mTOR signaling pathway also plays a crucial role in cell survival and metabolism

Drug tolerance for the low-concentration PC was established to be a free drug concentration in blood of approximately 4583.8 ng/mL for monkeys and 6610.4 ng/mL for rats

The maladaptive changes in the dopaminergic system further emphasize the role of neurotransmitter receptor remodeling in the development of mood disorders