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BDNF signaling through postsynaptic TrkB receptors is essential for the insertion of AMPARs (AMPA-type receptors) for postsynaptic density and the development of mature synapses [61]

Peters GJ, van der Wilt CL, van Moorsel CJ, Kroep JR, Bergman AM, Ackland SP

Unlike normal immune responses that target pathogenic invaders like viruses and bacteria, autoimmune reactions direct defensive mechanisms against self-tissues, creating inflammation, dysfunction, and sometimes permanent damage in affected areas

Human clinical trial data are absent

[cited 2021 Nov 24] 13

The figures below combine established pharmaceutical data and animal model extrapolation, labeled accordingly