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It means there is not enough evidence to guarantee safety

Other dermatologic adverse reactions reported with oral tretinoin include rash (unspecified) (54%), pruritus (20%), alopecia (14%), unspecified skin changes (14%), cellulitis (8%), facial edema (6%), and pallor (6%)

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doi: 10.2174/0115734072286081240326082701 79 YiY-S

But to me, the dose-dependent nature of it and the duration, to me, that's a very strong data that this is more causal than some corollary thing

This rigorous validation verifies the precise amino acid sequence maps, exact molecular weights, and correct spatial conformations while ensuring the total absence of residual synthesis reagents, truncated fragments, or raw contaminants