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We also created a GSH-insensitive control probe for validation studies

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The hypothesis that collagen in the tumor microenvironment can affect the outcome of cancer immunotherapy is supported by studies that have identified the serum level of the N-terminal pro-peptide of collagen type III (PRO-C3) as a marker of poor prognosis following anti-CTLA-4 and anti-PD-1 checkpoint inhibitor therapy in metastatic melanoma patients (183, 184)