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Animal model studies consistently show that pharmacological inhibition of ferroptosis or genetic upregulation of GPX4 expression leads to significantly reduced MMP and ADAMTS expression in cartilage tissue, accompanied by marked improvement in cartilage structural integrity (Dong et al., 2025

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The clinical features of an acute hyperammonaemic episode depend on the age of the patient and the cause of the elevation in plasma ammonia levels

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Vitamin B12 deficiency is frequently linked to: malabsorption disorders, severe malnutrition, some inherited imbalances in absorption, exocrine pancreatic insufficiency (EPI), chronic gastrointestinal disease and intestinal dysbiosis

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Gene 67 , 3140 (1988)

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[DOI] [PubMed] [Google Scholar] De Vivo DC, Bohan TP, Coulter DLDreifuss FE, Greenwood RS, Nordli DR, Jr, Shields WD, Stafstrom CE, Tein I

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