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The field requires comprehensive single-cell resolution mapping of AT microenvironments, longitudinal studies tracking dysfunction development from early metabolic stress to established disease, and systems-level integration of multi-omics data to identify causal relationships in metabolic regulation

[DOI] [PMC free article] [PubMed] [Google Scholar] 152.Armenian P., Gerona R.R., Blanc P.D., Wu A.H., Mookherjee S

[DOI] [PMC free article] [PubMed] [Google Scholar] 185.Camins A., Verdaguer E., Folch J., Palls M

You might notice this decline as increased fatigue, getting sick more easily, or skin that doesn't bounce back like it used to

Notably, by directly depleting SLC7A11, p53 decreases the activity of xCT to boost ferroptosis[151]

Despite gametocytemia being an important predictor of transmissibility to mosquitoes, other regulators such as human host, parasite, mosquito, drug and environmental factors may play important roles