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Certain histological characteristics of IC, such as the thinning of the bladder epithelium, erosion, and heightened mast cell infiltration, suggest that the condition may result from a deficiency in the regenerative capacity of bladder epithelial cells, along with immune system dysfunction (Slobodov et al., 2004)

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A well-prepared and thorough 483 response can resolve concerns before they grow into a formal warning letter, whereas a poor or delayed response almost invites one

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