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Abstract Deep-sea sediments host microbial communities essential to nitrogen, sulfur, and carbon cycling, yet those in the Southern Hemisphere remain understudied

This multi-axis neuroendocrine regulatory profile positions DSIP as a broad hypothalamic-pituitary axis modulator, not merely a sleep-specific peptide, and makes it a research tool for studying the neuroendocrine consequences of altered sleep homeostasis and circadian rhythm disruption