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J Nutr Biochem 18:113119 Pivari F, Mingione A, Brasacchio C, Soldati L (2019) Curcumin and type 2 diabetes mellitus: prevention and treatment

In one investigation, GHK-Cu was speculated to upregulate tight junction proteins ZO-1 and occludin in a co-culture model of epithelial-macrophage interaction (via the SIRT1/STAT3 pathway), thereby supporting tissue-barrier integrity in inflamed mucosa