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All of these molecules are aromatic receptor ligands that can prevent the activation of astrocytes and microglia by blocking pro-inflammatory transcription factors, thereby mediating brain homeostasis [48], among them, indole-3-acetic acid also plays a role in the negative effect of high-tryptophan diet on energy balance, thereby reducing the weight gain of rats

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This could explain why AUD patients showed increased intestinal permeability, primarily in the duodenum and jejunum, with limited changes in the ileum and colon [162]

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