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This secretion was independent of the virulence of the microorganisms tested, occurred only on the luminal aspect of the bacteria-exposed small intestinal mucosa, and was followed by an increase in intestinal permeability coincident with the disengagement of the protein zonula occludens (ZO)-1 from the tight junctional complex (4)

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This usually occurs at about four weeks

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AOD-9604 works through fat metabolism, not appetite suppression like GLP-1 medications