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Int J Mol Sci 26:2691

M.Arenas HernandezM.SmithM

It also acts as an intermediate in the pathway for valine, threonine, methionine, thymine, isoleucine, cholesterol and odd-chain fatty acids

Such an approach also appears within short reach, as the zonulin antagonist larazotide is already used in phase III clinical trial for the treatment of celiac disease and thus represents an accessible target molecule to accomplish this task

Taking into account the reaction geometry of thiol-disulfide exchange reactions, we raised the question which enzyme area interacts with which substrate 3,12 (Fig