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This abnormal bone remodeling further increases the mechanical burden on the joint, exacerbating OA symptoms ( Additionally, hypoxia-inducible factor 1 (HIF-1) is a key regulator of chondrocyte growth and survival, significantly influencing the state of subchondral bone

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Effects on the liver, kidneys, and nervous system

Urine constitutes a principal nutrient fraction of domestic wastewater, harboring approximately 80% of its nitrogen load and nearly 50% of its phosphorus content 125