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Patients with PAH have lower transcriptional levels of GPX3 in lung tissues, identifying GPX3 as a hypoxia-induced metabolism-associated hub gene, which could provide insight into the molecular mechanisms of hypoxic PAH and potential therapeutic targets [108]

Both PTEN and TP53 are frequently mutated in GBM, contributing to aggressive behaviour, treatment resistance, and poor prognosis 64,65,66,67