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R.De CamargoA

's study separated rats into five groups, and the immunohistochemistry results indicate that DSS (0.5, 1.0, and 2.0 mg/kg) significantly increased Bcl-2 expression in the cerebral area, while simultaneously inhibiting the expression of Bax and caspase-3

Huang SL, Hung CC, Jao CL, Tung YS, Hsu KC

However, more studies are still warranted for further exploration of other mechanistic molecular targets that may play role in the pathophysiology of cyclophosphamide-induced neurotoxicity such as involvement of protein oxidation and mitochondrial DNA damage in mediating this adverse effect

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