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Description

It is well documented that blockade of 5-HT 2 receptors attenuates antipsychotic-induced EPS associated with the striatal D 2 receptor blockade ( Figure 2 )

Importantly, neurotransmitters like GABA, dopamine and serotonin do not penetrate the blood-brain barrier, and as such they must be synthesized in the brain from local pools of neurotransmitter precursors