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Zhou N, Niu J, Nelson D, Feldman HA, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Swisher SG, Walsh GL, Giordano SH, Rajaram R

Instead, asparagine supplementation enhances the expression of glutamine synthetase (GLUL) and increases intracellular glutamine usage via glutaminolysis, resulting in the recovery of global protein translation that is blocked by glutamine deprivation 45

Recently, an interesting study identified dihydroorotate dehydrogenase (DHODH) as a novel ferroptosis suppressor that functions as independent of the classical GPX4 signaling pathway and revealed the mitochondrial lipid peroxidation-dependent ferroptosis pathway [79]