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Because BPC-157 is actively listed in Category 2, the FDA has determined that it poses significant safety risks, specifically regarding immunogenicity, structural impurities, and a distinct lack of human safety data

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doi: 10.1083/jcb.200303026

The strong recommendation of TNF inhibitors over JAK inhibitors is based on the fact that the most frequent form of IBD in patients with axSpA is Crohns disease, and at the time of the literature review for this Evidence-Based Guideline tofacitinib was the only JAK inhibitor approved for the treatment of IBD, and only for ulcerative colitis

Patel, thank you so much for being here