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"Regulatory Considerations in the Production of Research-Grade Peptides." Regulatory Toxicology and Pharmacology, 124, 105009.

Originally developed as an anti-obesity drug candidate in the late 1990s, it has since found research applications in both metabolic studies and cartilage repair investigations

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This gives it a half-life long enough to support once-weekly dosing, a major practical advantage over earlier amylin-based therapies like pramlintide, which required multiple daily injections

However, prolonged inflammation impairs the microglial cells' ability to bind and phagocytose A, diminishes the activity of A-degrading enzymes, and weakens their capacity to disintegrate A plaques [199, 200]

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