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This gap is widely recognized as a central barrier to translation, because the multisystem benefits of exercise arise from coordinated adaptations across immune, vascular, metabolic, endocrine, and neural compartments that are difficult to reproduce with any single agent [31]

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Interventions such as the antioxidant NAC or the inhibition of MAPK8/JNK activity have been demonstrated to mitigate ROS-induced parthanatos in glioma cells [156], suggesting that MAPK8 activation contributes to parthanatos by enhancing intracellular ROS levels

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