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Ejskjaer N, Vestergaard ET, Hellstrom PM, et al

A 180-pound person needs at least 90 ounces, about 2.6 liters

In the STEP trial published in the New England Journal of Medicine in 2021, adults with obesity who received semaglutide along with lifestyle guidance achieved significant reductions in body weight over 68 weeks

This is the fundamental trade-off of reconstitution, and it is worth internalizing directly: the diluent volume is a free parameter chosen by the researcher, and it changes only the measurement resolution how many syringe marks a given mass spreads across never the total mass in the vial