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this results in reduced transcription of mitochondrial ribosomal proteins and mitochondrial transcription factors, and subsequently halting protein translation 101,102

However, in case of not improving nodules with pain, tenderness, or erythema, intervention is necessary (90)

Risks and Considerations: Some patients may experience a temporary increase in pain or swelling following the injection

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The standard titration schedule of 4 weeks per dose level is a minimum, not a mandate

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