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Notwithstanding the considerable advances made by Pt nanozymes in antimicrobial, anti-inflammatory, and antitumor applications, the specific in vitro enzyme catalytic mechanisms underlying their therapeutic effects remain largely unknown

The FDA made its decision to withdraw approval after a new study failed to confirm Pepaxtos clinical benefit

For lysates preparation ( 31 ), cultures were centrifuged (10,000 g, 15 minutes), washed twice with potassium phosphate buffer (100 mM, pH 7.0), resuspended in borate buffer (50 mM, pH=8.4), and broken by mechanical lysis with glass beads in a tissue lyser (Qiagen, Courtaboeuf, France) 10 minutes, 50 Hz

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