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For example, the cardioprotective E3 ligase HectD3 suppresses Calcineurin-NFAT signaling and inflammatory stress by targeting SUMO2 and Stat1, thereby mitigating hypertrophic remodeling

Saleh & Sedik, 2024)

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This decline is one of the mechanisms behind the fatigue, cognitive slowing, and reduced physical resilience that patients often attribute to just getting older. A comprehensive review published in Cell Metabolism documenting the age-related decline in NAD levels and the downstream effects on mitochondrial function, cellular repair, and energy metabolism across tissue types

Ferroptosis in cancer cell biology