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doi:10.1136/practneurol-2014-001071

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Additionally, it has a specialized, inducible signaling function, where the PKA-HSL axis in M2 cells is highly activated to produce specific mediators that coordinate the complete pro-resolving program

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Loss of methylation of the ICR1 on the paternal allele results in the phenotype of Silver Russell syndrome (SRS) which may also arise from other genetic aberrations that have not yet been linked to the IGF-II production or signaling cascade including maternal uniparental dyssomnia of chromosome 7

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