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This anatomical difference has a significant impact on the translation of preclinical studies from laboratory animals to humans, particularly for dose finding and the investigation of nasal delivery devices

doi:10.1016/j.ejmg.2019.103713

IGF-1 also induces IB- dephosphorylation in astrocytes, protecting them from TNF--stimulated degradation and inhibiting nuclear translocation of NF-B (p65) in response to TNF- exposure, exerting potent anti-inflammatory effects [208]