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Developing smart delivery platforms for efficient glutamine metabolism disruption can minimize toxicity and improve therapeutic effects (Zhao et al., 2022)

On one hand, AMPK blocks NF- B nuclear translocation and reduces the transcription and release of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-) and interleukin-6 (IL-6) by enhancing the stability of inhibitor of nuclear factor B alpha (I B ) (Wang et al., 2024a)

Brebner, K., Childress, A

When they looked back at these errors, they realized that for two of them, if they had questioned the patients or called the prescribers, the errors may have been avoided entirely

Beside pancreas and gut, liver as component of the gastrointestinal tract has also been reported to be affected in cancer cachexia as described in the following section

These iron ions can exacerbate oxidative stress by catalyzing Fenton and Haber-Weiss reactions, leading to the production of ROS and reactive nitrogen species, which subsequently cause damage to brain cells (Fila et al., 2024)