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For example, nanoparticles have been constructed with individual or multiple versions of the full spike protein or RBD region and presented in high-order antigen arrays in native-like conformations (reviewed in ref

References Al-Shamery N, Biyashev D, Blancafort L et al (2025) From melanogenesis to melanin technologies

[DOI] [PubMed] [Google Scholar] [44].Schall N, Page N, Macri C

Still, some protocols include breaks every 1216 weeks to prevent plateauing and maintain long-term responsiveness

10.3390/ijms20194968 55 KandasamyP.GyimesiG.KanaiY.HedigerM

Hu Y, Chen D, Zheng P, Yu J, He J, Mao X et al (2019) The bidirectional interactions between resveratrol and gut microbiota: an insight into oxidative stress and inflammatory bowel disease therapy