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Brain 54 LiaoS.ApaijaiN.LuoY.WuJ.ChunchaiT.SinghanatK.et al (2021)

Science 250, 10021004

During these visits, the study team will collect information related to your skin condition and weight

PC, protein carbonyl

2b)and the emerging recognition of BCL-2 as a survival factor driving castration resistance, here we sought to define how AR +/- BCL-2 +/- PCa cell subtypes dynamically evolve in response to castration and during progression to CRPC, understand how AR signaling controls BCL-2 expression in different androgen signaling environments, and, critically, determine whether BCL-2 represents a shared, therapeutically actionable resistance mechanism across distinct CRPC subtypes