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Local rashes most often come from three mechanisms: An immune response to the medication itself, sending histamine to the injection area Sensitivity to an inactive ingredient like a preservative or buffer in the formulation Mechanical trauma from the needle or a fast injection technique The immune explanation is straightforward: a neighborhood-level alarm that sends histamine and inflammatory signals, producing redness and itch

Ongoing Monitoring As your body responds, your provider may adjust your protocol, dosing, frequency, or supportive care recommendations

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The mechanism behind these reactions typically involves a localized inflammatory response